Effect of in vivo depletion of CD4+ and CD8+ cells on the induction and maintenance of oral tolerance
| Autor: | J. Gabriel Michael, Shilpa L. Jain, K.Siobhan Barone |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
CD4-Positive T-Lymphocytes
Ovalbumin T cell Immunology Cell Administration Oral Clonal Deletion Mice Inbred Strains Biology Pharmacology CD8-Positive T-Lymphocytes Lymphocyte Activation Mice Immune system In vivo medicine Immune Tolerance Animals Oral tolerance Regeneration (biology) Immunization Passive Flow Cytometry Molecular biology medicine.anatomical_structure Oral tolerization Female Lymph Nodes CD8 |
| Zdroj: | Cellular immunology. 163(1) |
| ISSN: | 0008-8749 |
| Popis: | The role of CD8+ and CD4+ cells in the generation and maintenance of high-dose oral tolerance has been investigated. Mice depleted of CD8+ cells prior to or subsequent to oral tolerization with OVA continued to express suppressed humoral and/or T cell proliferative responses to the homologous antigen. To assess the effect of CD4+ cell depletion on oral tolerance, mice were depleted of CD4+ cells prior to or subsequent to oral tolerization with OVA. After 50% regeneration of CD4+ cells was achieved, OVA-immunized mice produced anti-OVA immune responses that were comparable to those of water-fed control mice. Thus, under our experimental conditions the presence of CD4+ but not CD8+ cells is required to both establish and maintain oral tolerance. |
| Databáze: | OpenAIRE |
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