A single episode of stress during adolescence impairs short-term memory and increases risk behaviour in an animal model of attention-deficit/hyperactivity disorder
Autor: | Pablo Pandolfo, Arnaldo de Sá Geraldo, Ícaro Raony |
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Rok vydání: | 2020 |
Předmět: |
0106 biological sciences
Adolescent Short-term memory 010603 evolutionary biology 01 natural sciences Behavioral Neuroscience Animal model Risk-Taking Rats Inbred SHR Stress (linguistics) Medicine Attention deficit hyperactivity disorder Animals Humans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Recognition memory Risk behaviour business.industry 05 social sciences General Medicine medicine.disease Rats Disease Models Animal Memory Short-Term Attention Deficit Disorder with Hyperactivity Animal Science and Zoology Restraint stress Single episode business Clinical psychology |
Zdroj: | Behavioural processes. 187 |
ISSN: | 1872-8308 |
Popis: | Adolescence is a period of increased sensitivity to stress and vulnerability to the manifestation of psychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the relationship between stress during adolescence and ADHD is still unclear. Knowing that stress can have long-term consequences, the aim of this study was to evaluate the impact of a single episode of restraint stress during adolescence on locomotion, risk behaviour and short-term memory in adult spontaneously hypertensive rats (SHR), a validated animal model of ADHD. A single episode of stress during adolescence increased risk behaviour and impaired short-term recognition memory, but did not alter locomotion in adult SHR. These findings show that stress during adolescence, even acute, may lead to long-term behavioural consequences in an animal model of ADHD. |
Databáze: | OpenAIRE |
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