Human plasma cell-free DNA as a predictor of infectious complications of neutropenic fever in hematological patients
| Autor: | Matti Vänskä, Maija Lehtikangas, Anna-Kaisa Purhonen, Esa Jantunen, Kari Pulkki, Sari Hämäläinen, Auni Juutilainen, Irma Koivula, Päivi Lakkisto |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Adolescent Antineoplastic Agents Gastroenterology Sepsis Young Adult Internal medicine medicine Humans Chemotherapy-Induced Febrile Neutropenia Aged General Immunology and Microbiology business.industry Septic shock Organ dysfunction Neutropenic fever Myeloid leukemia General Medicine DNA Middle Aged medicine.disease Lymphoma Infectious Diseases Cell-free fetal DNA Shock (circulatory) Hematologic Neoplasms Immunology Female medicine.symptom business Biomarkers |
| Zdroj: | Infectious diseases (London, England). 47(4) |
| ISSN: | 2374-4243 |
| Popis: | Neutropenic fever is common in patients receiving intensive chemotherapy for hematological malignancies. The clinical course may be aggravated by infectious complications like severe sepsis, septic shock or even death. We prospectively studied 100 patients with neutropenic fever and evaluated human plasma cell-free DNA (cfDNA) during the first 3 days after the onset of fever as a prognostic biomarker for complicated clinical course, defined as sepsis or septic shock. Complicated course was observed in 21 patients (21%). There were no significant differences in cfDNA levels between the patients with or without complications on any study day when all the patients were analyzed as one group. In subgroups according to hematological malignancy, patients with acute myeloid leukemia (AML) had lower cfDNA levels than patients with lymphoma. Among AML patients d0 cfDNA/leukocyte ratio and among lymphoma patients d0 cfDNA was associated with subsequent development of sepsis or septic shock. cfDNA deserves further studies in hematological patients with sepsis. |
| Databáze: | OpenAIRE |
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