Structural and biological survey of 7‐chloro‐4‐(piperazin‐1‐yl)quinoline and its derivatives

Autor:	Mohamed Nabil Aboul-Enein, Mohamed Farouk Hamissa, Aida Abd El-Sattar El-Azzouny
Rok vydání:	2020
Předmět:	2019-20 coronavirus outbreak biology Antiparasitic medicine.drug_class Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Quinoline Combinatorial chemistry Acetylcholinesterase Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Drug Discovery Sirtuin Quinolines medicine biology.protein Animals Humans Pharmacophore Serotonin Antagonists 030217 neurology & neurosurgery
Zdroj:	Drug Development Research
ISSN:	1098-2299 0272-4391
DOI:	10.1002/ddr.21678
Popis:	The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc37e9b3ce5a2b7fefcf325da2466517 https://doi.org/10.1002/ddr.21678 Zobrazit plný text záznamu Plný text