Visual development of human milk-fed preterm infants provided with extra energy and nutrients after hospital discharge
| Autor: | Mark Feldman, Carol A. Westall, Ann L Jefferies, Deborah L O'Connor, Hilary Whyte, Karen Weishuhn, Elizabeth Asztalos, Giuseppe Mirabella, Douglas M Campbell, Joanne Rovet |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Visual acuity Visual Acuity Medicine (miscellaneous) Gestational Age Nervous System law.invention Contrast Sensitivity Nutrient Randomized controlled trial law Hospital discharge Medicine Humans Infant Nutritional Physiological Phenomena Nutrition and Dietetics Milk Human Surrogate endpoint business.industry Infant Newborn Gestational age After discharge Infant Low Birth Weight Patient Discharge Low birth weight Food Fortified Female medicine.symptom business Energy Intake Infant Premature |
| Zdroj: | JPEN. Journal of parenteral and enteral nutrition. 36(3) |
| ISSN: | 1941-2444 |
| Popis: | Human milk (HM) is the optimal way to nourish preterm low birth weight (LBW) infants after hospital discharge. However, there are few data on which to assess whether HM alone is sufficient to address hospital-acquired nutrition deficits, and no adequately powered studies have examined this question using neurodevelopment as an outcome. The purpose of this work was to determine whether adding extra energy and nutrients to the feedings of predominantly HM-fed LBW infants early after discharge improves their visual development. Visual development was used in this study as a surrogate marker for neurodevelopment.At discharge, 39 predominantly HM-fed LBW infants (750-1800 g, 1288 ± 288 g) were randomized to receive human milk alone (control) or around half of the HM received daily mixed with a multinutrient fortifier (intervention) for 12 weeks. Grating acuity (ie, visual acuity) and contrast sensitivity were assessed using sweep visual-evoked potential tests at 4 and 6 months corrected age.At 4 and 6 months corrected age, intervention infants demonstrated higher grating acuity compared to those in the control group (intervention: 7.8 ± 1.3 and 9.7 ± 1.2 [cycles/degree] vs control 6.9 ± 1.2 and 8.2 ± 1.3, P = .02). Differences in contrast sensitivity did not reach statistical significance (P = .11).Adding a multinutrient fortifier to a portion of the expressed breast milk provided to predominantly HM-fed LBW infants early after discharge improves their early visual development. Whether these subtle differences in visual development apply to other aspects of development or longer term neurodevelopment are worthy of future investigation. |
| Databáze: | OpenAIRE |
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