Adjunctive Use of Noninvasive Ventilation During Exercise in Patients With Decompensated Heart Failure
| Autor: | Marcos Brandmuller Fernandes, Karen Kimoto, Wellington Pereira Yamaguti, Igor Gutierrez Moraes, Samantha Torres Grams |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology law.invention 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Randomized controlled trial Double-Blind Method law Internal medicine Medicine Humans In patient Continuous positive airway pressure Exercise Aged Aged 80 and over Heart Failure Ejection fraction Cross-Over Studies Exercise Tolerance Noninvasive Ventilation Continuous Positive Airway Pressure business.industry Stroke Volume Stroke volume Middle Aged medicine.disease Crossover study Hospitalization Dyspnea 030228 respiratory system Heart failure Breathing Cardiology Exercise Test Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American journal of cardiology. 119(3) |
| ISSN: | 1879-1913 |
| Popis: | Noninvasive ventilation (NIV) as an adjunct strategy for increasing exercise tolerance has been widely investigated in patients with pulmonary diseases. To our knowledge, there are no studies that have used NIV during exercise in patients with decompensated heart failure (HF). The aim of this study was to evaluate the effects of NIV on exercise tolerance in hospitalized patients with decompensated HF. Thirteen patients (77 ± 15 years) with a mean left ventricular ejection fraction of 35 ± 15% were included. Patients underwent 2 submaximal exercise tests with constant load for lower limbs using a portable cycle ergometer. Tests were performed on the same day with a 60-minute interval between each one, using a randomized crossover design: sham ventilation (continuous positive airway pressure mode, 4 cm H 2 O) and intervention situation (NIV in bilevel mode). Primary outcome was the endurance time performed during exercise tests with constant load. Submaximal exercise with NIV in bilevel mode improved endurance time (7.2 ± 2.7 minutes) compared to the tests performed with continuous positive airway pressure (5.1 ± 1.5 minutes; p = 0.008). Increase in endurance time (Δ time) with bilevel test showed a significant correlation with reduction in the slope of dyspnea (Δ Borg) over time ( r = −0.73; p = 0.004). There was a significant correlation between endurance time in bilevel tests and maximum inspiratory pressure % predicted ( r = 0.68; p = 0.02). In conclusion, NIV was effective in increasing exercise tolerance in hospitalized patients with decompensated HF. (ClinicalTrials.gov registration NCT02122848). |
| Databáze: | OpenAIRE |
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