Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis
| Autor: | Claudia Stefanutti, Luis E. Simental-Mendía, Amirhossein Sahebkar, Matteo Pirro |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Coenzyme Q(10) Lipids Lipoprotein(a) Nutraceuticals Cardiovascular Diseases Humans Risk Factors Ubiquinone Dietary Supplements medicine.medical_specialty 030204 cardiovascular system & hematology law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Internal medicine Coenzyme Q10 Pharmacology medicine biology Triglyceride Cholesterol PCSK9 Confidence interval 030104 developmental biology Endocrinology Mitochondrial respiratory chain chemistry biology.protein |
| Zdroj: | Pharmacological research. 105 |
| ISSN: | 1096-1186 |
| Popis: | Plasma lipoprotein(a) [Lp(a)] elevations are associated with increased cardiovascular risk. Coenzyme Q10 (CoQ10) is a member of the mitochondrial respiratory chain with a prominent role as a potent gene regulator. The Lp(a)-lowering efficacy of CoQ10 has been investigated in different clinical settings with contrasting results. A systematic literature search in Medline, SCOPUS, Web of Science and Google Scholar databases was conducted to identify controlled trials investigating the efficacy of CoQ10 supplementation on plasma Lp(a) levels. Inverse variance-weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated for net changes in Lp(a) levels using a random-effects model. Random-effects meta-regression was performed to assess the effect of putative confounders on plasma Lp(a) levels. Seven randomized controlled trials with a total of 409 subjects (206 in the CoQ10 arm and 203 in the control arm) met the eligibility criteria. Overall, CoQ10 supplementation was paralleled by a slight but significant reduction of plasma Lp(a) levels (WMD: -3.54 mg/dL, 95% CI: -5.50, -1.58; p |
| Databáze: | OpenAIRE |
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