The Effect Of Msh On Thymidine Incorporation By Keratinocytes In The Epidermal Melanin Unit
| Autor: | Funan Hu, Luigi Giacometti, Kent L. Erickson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
endocrine system
medicine.medical_specialty Guinea Pigs Labeling index Dermatology Biology Biochemistry Melanin chemistry.chemical_compound Internal medicine medicine Animals Melanocyte-Stimulating Hormones Molecular Biology Skin Cell Nucleus Melanins integumentary system Cell Biology Molecular biology Thymidine incorporation Microscopy Electron medicine.anatomical_structure Endocrinology chemistry Autoradiography Keratins Melanocytes Keratinocyte Thymidine hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Journal of Investigative Dermatology. 66(6):367-370 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12482975 |
| Popis: | Epidermal melanocytes were observed in the black but not in the white skin of black-and-white spotted guinea pigs. In experiments designed to determine whether melanocyte-stimulating hormone (MSH) affects the incorporation of thymidine by keratinocyte nuclei of the epidermal melanin unit, the labeling index was the same in all skin before MSH administration. After MSH injections, the level of [ 3 H]thymidine incorporation in keratinocytes increased significantly in black skin but not in white. We suggest that through the mediation of melanocytes MSH indirectly affects keratinocytes in the epidermal melanin unit. |
| Databáze: | OpenAIRE |
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