Placental tumor necrosis factor-α protein expression during normal human gestation
| Autor: | Nerys Benfield, Enyonam Agamasu, Carolyn M. Salafia, Magdy Mikhail, Bolek Bendek, Aruna Mishra, Priya Prasad, Jayasri Basu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Vascular smooth muscle Placenta Gestational Age Matrix metalloproteinase Statistics Nonparametric 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy Internal medicine medicine Decidua Humans 030219 obstetrics & reproductive medicine business.industry Tumor Necrosis Factor-alpha Obstetrics and Gynecology medicine.disease Trophoblasts Up-Regulation 030104 developmental biology medicine.anatomical_structure Endocrinology Pediatrics Perinatology and Child Health Chorionic villi Gestation Tumor necrosis factor alpha Female Chorionic Villi business |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 29(24) |
| ISSN: | 1476-4954 |
| Popis: | Placental tumor necrosis factor-α (TNF-α) is a cell signaling protein. During pregnancy, TNF-α induces synthesis of matrix metalloproteinases (MMPs) which allows cytotrophoblasts to reach the spiral arteries deeper within the uterine decidua. TNF-α also augments apoptosis of vascular smooth muscle cells surrounding these arteries. In this study, chorionic villi TNF-α protein expression throughout normal human gestation were investigated.Placental chorionic villi tissues obtained from elective surgical terminations of pregnancy and from uncomplicated term births were assayed using EIA kits (Cayman Chemicals, Ann Arbor, MI, Item # 589201).The median, 25th percentile and 75th percentile values in the first (N = 99), second (N = 58) and third trimester (N = 42) were: 36.46, 27.25, 45.90 pg/100 mg tissue; 55.43, 40.09, 110.88 pg/100 mg tissue; and 16.63, 9.32, 31.92 pg/100 mg tissue, respectively.Variations in placental TNF-α protein expression noted at different trimesters may suggest gestational age specific roles for the cytokine. The increase in TNF-α protein expression observed in the second trimester may be involved in upregulating synthesis of MMP and in augmenting apoptosis of vascular smooth muscle cells of the spiral arteries. A failure in this second trimester increase in TNF-α protein could contribute to gestational compromise. |
| Databáze: | OpenAIRE |
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