Intercepting Parkinson disease non-motor subtypes. a proof-of-principle study in a clinical setting
| Autor: | M. E. Di Battista, Alfonso Rubino, Nicola Vanacore, Esterina Pascale, C.P. Papi, Giuseppe Meco, Simone Pomati, Francesco Fattapposta, Ilaria Cova, Carlo Purcaro, Nicoletta Locuratolo, G. Alampi, Claudio Mariani |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Parkinson's disease Models Neurological Population tau Proteins Translational research Disease Neuropsychological Tests non motor subtypes microtubule associated protein tau (mapt) non motor symptoms parkinson's disease neurology neurology (clinical) Proof of Concept Study Cohort Studies 03 medical and health sciences 0302 clinical medicine Humans Medicine education Cognitive impairment Aged Aged 80 and over education.field_of_study business.industry Parkinson Disease Middle Aged Neuropsychological battery medicine.disease Subtyping 030104 developmental biology Haplotypes Feasibility Studies Non motor Female business Neuroscience 030217 neurology & neurosurgery |
| Popis: | The construct of non-motor symptoms (NMS) subtyping in Parkinson Disease (PD) is emerging as a line of research in the light of its potential role in etiopathological interpretation of PD heterogeneity. Different approaches of NMS subtyping have been proposed: an anatomical model suggests that NMS aggregate according to the underpinning pathology; other researchers find aggregation of NMS according to the motor phenotype; the contribution of genetic background to NMS has also been assessed, primarily focusing on cognitive impairment. We have analyzed NMS burden assessed through an extensive clinical and neuropsychological battery in 137 consecutive non-demented PD patients genotyped for MAPT haplotypes (H1/H1 vs H2 carriers) in order to explore the applicability of the "anatomo-clinical", "motor" or "genetic" models for subtyping PD in a clinical setting; a subsequent independent analysis was conducted to verify a possible cluster distribution of NMS. No clear-cut NMS profiles according to the previously described models emerged: in our population, the autonomic dysfunctions and depressive symptoms represent the leading determinant of NMS clusters, which seems to better fit with the hypothesis of a "neurotransmitter-based" model. Selective preferential neurotransmitter network dysfunctions may account for heterogeneity of PD and could address translational research. |
| Databáze: | OpenAIRE |
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