Prostate cancer patients may have an increased risk of coexisting advanced colorectal neoplasms
| Autor: | Pumsoo Kim, Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Woong Jin Bae |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer Colonoscopy Malignancy OncoTargets and Therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine colonoscopy Internal medicine medicine Pharmacology (medical) Original Research medicine.diagnostic_test business.industry Odds ratio colorectal neoplasms medicine.disease prostate cancer colorectal adenoma and carcinoma Dysplasia colorectal adenomaand carcinoma 030220 oncology & carcinogenesis Adenocarcinoma 030211 gastroenterology & hepatology business Body mass index |
| Zdroj: | OncoTargets and therapy ONCOTARGETS AND THERAPY(9) |
| ISSN: | 1178-6930 |
| Popis: | Sun-Hye Ko,1,2 Myong Ki Baeg,2,3 Woong Jin Bae,4 Pumsoo Kim,3 Myung-Gyu Choi2 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 3Department of Internal Medicine, International St Mary’s Hospital, Catholic Kwandong University, Incheon, South Korea; 4Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, South Korea Background/aims: Patients being treated for prostate cancer (PCa) have an increased risk of developing colorectal cancer. However, whether PCa patients are inherently at a higher risk of colorectal neoplasms (CRNs) is unknown. We aimed to investigate the risk of CRNs in PCa patients.Materials and methods: Patients who had been diagnosed with PCa at a tertiary medical center and had colonoscopy within 1 year of the PCa diagnosis were investigated. Patients were propensity-matched 1:2 by age and body mass index to asymptomatic control subjects who had undergone colonoscopy for routine health screening. CRN was defined as histological confirmation of an adenoma or adenocarcinoma component. Advanced CRN was defined as any of the following: 1) histological findings of high-grade dysplasia, 2) inclusion of villous features, 3) tumor ≥1 cm in size, or 4) presence of an adenocarcinoma. Risk factors for CRN and advanced CRN were evaluated by univariate and multivariate analysis.Results: A total of 191 patients diagnosed with PCa had colonoscopies within 1 year of PCa diagnosis. Of these, 23 patients with a history of previous malignancy and seven with incomplete colonoscopies were excluded, leaving 161 patients in the PCa group. Although presence of PCa was not a significant risk factor for CRN by multivariate analysis, PCa was a significant risk factor for advanced CRN (odds ratio [OR] 3.300; 95% confidence interval [CI] 1.766–6.167; P |
| Databáze: | OpenAIRE |
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