Kisspeptin and RFRP-3 differentially regulate food intake and metabolic neuropeptides in the female desert jerboa
| Autor: | Rabia Magoul, Rajae Talbi, Seloua El Ouezzani, Marie-Pierre Laran-Chich, Valérie Simonneaux |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Sidi Mohamed Ben Abdellah (USMBA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Food intake endocrine system media_common.quotation_subject [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Hypothalamus Neuropeptide Rodentia Biology Article 03 medical and health sciences Eating 0302 clinical medicine Kisspeptin Kisspeptins Internal medicine Orexigenic [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology medicine Animals media_common 2. Zero hunger Neurons Multidisciplinary Reproduction digestive oral and skin physiology Neuropeptides Fasting 030104 developmental biology Endocrinology Female Seasons Shut down 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2016, 6, pp.36057. ⟨10.1038/srep36057⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep36057⟩ |
| Popis: | Jerboas are wild rodents exhibiting exceptional adaptation to their desert environment. Under harsh autumn conditions, they shut down reproduction, increase body weight and hibernate, while during spring they become sexually active even under negative energy-balance. We recently reported that these rhythms are associated with synchronized changes in genes expressing reproductive (Kiss1, Rfrp) and metabolic (Npy and Pomc) peptides, raising the hypothesis of coordinated seasonal regulation of both functions. Here we analyzed whether kisspeptin and RFRP-3 regulate food-intake in parallel to their established reproductive functions. Intracerebroventricular administration of kisspeptin inhibited food intake by 1.5-fold in fasted, but not ad-libitum fed, female jerboas captured in spring, an effect associated with an increase in Pomc and decrease in Rfrp mRNA levels. By contrast, intracerebroventricular injection of RFRP-3 induced a 4-fold increase in food-intake in ad-libitum female jerboas, together with a decrease in Pomc and increase in Npy mRNA levels. This orexigenic effect of RFRP-3 was observed in both spring and autumn, whereas kisspeptin’s anorexigenic effect was only observed in spring. Altogether, this study reports opposite metabolic effects of kisspeptin and RFRP-3 in the female jerboa and strengthens our hypothesis of a coordinated, season-dependent, regulation of reproductive activity and food intake through interactions of these hypothalamic peptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|