Heterocellular induction of interferon by negative-sense RNA viruses
| Autor: | Marian J. Killip, M. Schneider, S. Chen, Steve Goodbourn, Jessie Short, D. F. Young, Richard E. Randall |
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| Rok vydání: | 2010 |
| Předmět: |
Influenza bunyamwera
Paramyxoviridae viruses Kidney Virus Replication medicine.disease_cause Article Virus Microbiology 03 medical and health sciences Paramyxovirus Species Specificity Bunyamwera virus Interferon Cell Line Tumor Virology Chlorocebus aethiops medicine Influenza A virus Animals Humans Lung Vero Cells 030304 developmental biology 0303 health sciences biology 030302 biochemistry & molecular biology Interferon-alpha RNA Interferon-beta biology.organism_classification 3. Good health Viral replication Host-Pathogen Interactions Interferon Type I Interferon type I medicine.drug |
| Zdroj: | Virology |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2010.08.008 |
| Popis: | The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. |
| Databáze: | OpenAIRE |
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