Oral Candida colonization in oral cancer patients and its relationship with traditional risk factors of oral cancer: A matched case-control study
| Autor: | Michael McCullough, Eric C. Reynolds, Neil M O'Brien-Simpson, David Wiesenfeld, Ali D. Alnuaimi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Biology Gastroenterology Young Adult Risk Factors Internal medicine Genotype medicine Humans Young adult Candida albicans Aged Candida Aged 80 and over Mouth neoplasm Mouth Incidence (epidemiology) Case-control study Cancer Middle Aged biology.organism_classification medicine.disease Corpus albicans Oncology Case-Control Studies Female Mouth Neoplasms Oral Surgery |
| Zdroj: | Oral Oncology. 51:139-145 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/j.oraloncology.2014.11.008 |
| Popis: | Summary Objectives Candida, an opportunistic fungal pathogen, has been implicated in oral and oesophageal cancers. This study aimed to examine oral Candida carriage in 52 oral cancer patients and 104 age-, gender- and denture status-matched oral cancer-free subjects. Material and methods We assessed general health, smoking and alcohol drinking habits, use of alcohol-containing mouthwash and periodontal status (community periodontal index of treatment needs). Yeasts were isolated using oral rinse technique and genetically identified via Real-Time PCR-High resolution melting curve analysis of conserved ribosomal DNA. Conditional and binary logistic regressions were used to identify explanatory variables that are risk factors for oral cancer. Results and conclusion The frequencies of oral yeasts’ presence and high oral colonization were significantly higher in oral cancer than non-oral cancer patients (p = 001; p = 0.033, respectively). No significant difference in the isolation profile of Candida species was found between the two groups, except C. parapsilosis was more frequent in non-oral cancer group. Differences were noticed in the incidence of C. albicans strains where significantly more C. albicans genotype-A was isolated from cancer patients and significantly more C. albicans genotype-B isolated from non-cancer patients. Multiple regression analyses showed significant association with cancer observed for alcohol drinking (OR = 4.253; 95% CI = 1.351, 13.386), Candida presence (OR = 3.242; 95% CI = 1.505, 6.984) and high oral colonization (OR = 3.587; 95% CI = 1.153, 11.162). These results indicate that there is a significant association between oral cancer occurrence and Candida oral colonization and that the observed genotypic diversity of C. albicans strains may play a role in oral carcinogenesis. |
| Databáze: | OpenAIRE |
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