Interleukin-1β stimulates adrenocorticotropin and corticosterone release in 10-day-old rat pups
| Autor: | Robert A. Menzies, Nicholas Hall, Maureen P. O'Grady |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System medicine.medical_specialty Endocrinology Diabetes and Metabolism Ontogeny medicine.medical_treatment Central nervous system Radioimmunoassay Pituitary-Adrenal System Biology Rats Sprague-Dawley chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Corticosterone In vivo Internal medicine medicine Animals Biological Psychiatry Endocrine and Autonomic Systems Psychoneuroimmunology Recombinant Proteins Rats Psychiatry and Mental health Steroid hormone medicine.anatomical_structure Cytokine Animals Newborn chemistry Adrenal Cortex Female Glucocorticoid Interleukin-1 medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 18:241-247 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/0306-4530(93)90007-8 |
| Popis: | Interleukin-1 (IL-1) is a cytokine secreted in response to immunological challenge which has effects in many physiological systems in adult models. Among the central nervous system effects of IL-1 are its ability to alter sleep patterns, body temperature, and certain neuroendocrine parameters including the release of ACTH and corticosterone (B) in vivo. This study investigated the ability of IL-1 to induce ACTH and B release in 10-day-old rats. This age was chosen due to a well documented phenomenon, the stress hyporesponsive period (SHRP), in which rodents display a blunted pituitary-adrenal response to stressors during the first 2 postnatal weeks (postnatal days 3-14). Administration of IL-1 to rat pups during the SHRP resulted in robust ACTH and B increases. Data are discussed in terms of the site of action and ontogeny of negative feedback mechanisms in the hypothalamic-pituitary-adrenal axis. |
| Databáze: | OpenAIRE |
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