Prognostic and clinicopathological significance of MUC expression in head and neck cancer: a systematic review and meta-analysis
| Autor: | Dan Liang, Wenjun Yang, Wanlin Xu, Hao Lu, Yun Zhu, Kai-Hua Zhou, Shengwen Liu, Limin Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Lymph node metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine MUC medicine Overall survival In patient Stage (cooking) business.industry Head and neck cancer Mucin biomarkers medicine.disease 030104 developmental biology Clinical research 030220 oncology & carcinogenesis Meta-analysis head and neck cancer prognosis business Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Hao Lu 1,2,* , Dan Liang 3,* , Yun Zhu 1,2 , Wanlin Xu 1,2 , Kaihua Zhou 1,2 , Limin Liu 1,2 , Shengwen Liu 1,2 and Wenjun Yang 1,2 1 Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, China 3 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China * These authors have contributed equally to this work Correspondence to: Wenjun Yang, email: // Shengwen Liu, email: // Keywords : MUC, head and neck cancer, biomarkers, prognosis, meta-analysis Received : December 23, 2016 Accepted : February 28, 2017 Published : July 27, 2017 Abstract The prognostic value of mucins expression in patients with head and neck cancer (HNC) remains controversial. To address this, a meta-analysis was performed to systematically evaluate prognostic significance of mucins expression in HNC. Electronic and manual searches were performed and a total of 20 studies including 2046 patients were selected for the final analysis. Increased mucins expression was associated with unfavorable overall survival in HNC patients (HR=1.83, 95% CI: 1.43-2.33, p =0.000). Mucins overexpression was also in correlation with more advanced TNM stage (RR=0.84, 95% CI: 0.73-0.97, p =0.017), higher risk of lymph node metastasis (RR=0.69, 95% CI: 0.57-0.84, p =0.000) and deeper invasion (RR=0.58, 95% CI: 0.44-0.76, p =0.000). These results suggested that elevated mucins expression was significantly associated with worse prognosis and more detrimental clinicopathological outcomes, revealing the promising potential of mucins as biomarkers for HNC management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|