Case Report: Meningoencephalomyelitis of Unknown Etiology Manifesting as a Bilateral Cranial Polyneuropathy in 3 Dogs
| Autor: | Rachel Lampe, Hilary A. Levitin, Silke Hecht |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty 040301 veterinary sciences brain Population Central nervous system canine Case Report Neurological examination inflammatory MUE 0403 veterinary science 03 medical and health sciences Cerebrospinal fluid medicine MUO Pleocytosis education 030304 developmental biology cranial nerve 0303 health sciences education.field_of_study lcsh:Veterinary medicine General Veterinary medicine.diagnostic_test business.industry Cranial nerves 04 agricultural and veterinary sciences Spinal cord medicine.disease medicine.anatomical_structure lcsh:SF600-1100 Veterinary Science business Polyneuropathy |
| Zdroj: | Frontiers in Veterinary Science Frontiers in Veterinary Science, Vol 7 (2020) |
| ISSN: | 2297-1769 |
| DOI: | 10.3389/fvets.2020.00326 |
| Popis: | A bilateral cranial polyneuropathy was the primary magnetic resonance imaging (MRI) finding in three medium to large breed dogs diagnosed with meningoencephalomyelitis of unknown etiology. All three dogs presented with a progressive history of vestibular ataxia with either central vestibular or multifocal central nervous system (CNS) neuroanatomical localization. Brain MRI revealed variable degree of bilateral enlargement and/or increased contrast enhancement of the optic, oculomotor, trigeminal, facial, and vestibulocochlear nerves, as well as enhancement of the orbital fissure (oculomotor, trochlear, ophthalmic branch of trigeminal, and abducens nerves). There was evidence of intracranial and cranial cervical meningeal contrast enhancement in all three dogs and of cervical spinal cord lesions in 2. In all cases, more cranial nerves were affected than indicated by neurological examination. Cerebrospinal fluid (CSF) analysis was consistent with a mononuclear pleocytosis in 2 cases and a mixed cell (predominantly lymphocytic) pleocytosis in 1 case. All dogs were treated with immune suppressing medications and showed clinical improvement, although some cranial nerve deficits were persistent at follow up 2 months later. These are the first known cases of MUE diagnosed ante-mortem in a canine population documenting bilaterally symmetrical lesions affecting multiple cranial nerves. While MUE is a common cause of non-infectious inflammatory disease in dogs, it likely encompasses more classifications than have previously been reported, and should remain a differential for dogs of all ages and sizes presenting with cranial nerve deficits. |
| Databáze: | OpenAIRE |
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