NMDA-receptor blockade by CPP impairs post-training consolidation of a rapidly acquired spatial representation in rat hippocampus
| Autor: | Matthew R. Holahan, Robert U. Muller, Nancy S. Hong, Robert J. McDonald, Laura A. Craig, Meira Louis |
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| Rok vydání: | 2005 |
| Předmět: |
Time Factors
Consolidation (soil) Behavior Animal General Neuroscience Hippocampus Retention Psychology Water maze Hippocampal formation Receptors N-Methyl-D-Aspartate Piperazines Blockade Rats Encoding (memory) Space Perception Reaction Time NMDA receptor Animals Memory consolidation Psychology Maze Learning Neuroscience Excitatory Amino Acid Antagonists |
| Zdroj: | The European journal of neuroscience. 22(5) |
| ISSN: | 0953-816X |
| Popis: | Recent evidence suggests that N-methyl-D-aspartate (NMDA)-receptor mediated plasticity in hippocampus has a more subtle role in memory-based behaviours than originally thought. One idea is that NMDA-based plasticity is essential for the consolidation of post-training memory but not for the initial encoding or for short-term memory. To further test this idea we used a three-phase variant of the hidden goal water maze task. In the first phase, rats were pre-trained to an initial location. Next, intense, massed training was done in a 2-h interval to teach the rats to go to a new location after either an injection of the NMDA receptor antagonist (6)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or of vehicle. Finally, under drug-free conditions 24 h after new location training, a competition test was done between the original and new locations. We find that N-methyl-D-aspartate (NMDA)-receptor blockade has little or no effect on new location training. In contrast, when tested 24 h later, the strength of the trace for the new location learned during NMDA-receptor blockade was much weaker compared with the trace for the new location learned after saline injection. Further experiments showed similar effects when NMDA-receptors were blocked immediately after the new location training, suggesting that this is a memory consolidation effect. Our results therefore reinforce the notion that hippocampal NMDA-receptors participate in post-training memory consolidation but are not essential for the processes necessary to learn or retain navigational information in the short term. |
| Databáze: | OpenAIRE |
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