Accumulation and tissue distribution of selected polychlorinated biphenyl congeners in chickens
| Autor: | R. De Schrijver, Shaogang Chu, Stefan Voorspoels, Johan Maervoet, Adrian Covaci, S. De Vos, Paul Schepens |
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| Rok vydání: | 2004 |
| Předmět: |
Chromatography
Gas Time Factors Environmental Engineering Health Toxicology and Mutagenesis Food Contamination Absorption (skin) Biology Absorption chemistry.chemical_compound Biotransformation Animals Environmental Chemistry Tissue Distribution Food science Analysis of Variance Persistent organic pollutant Public Health Environmental and Occupational Health Broiler food and beverages Polychlorinated biphenyl General Medicine General Chemistry Metabolism Animal Feed Polychlorinated Biphenyls Pollution Biochemistry chemistry Bioaccumulation Toxicity Chickens |
| Zdroj: | Chemosphere |
| ISSN: | 0045-6535 |
| Popis: | During one to three consecutive periods of 2 weeks, broiler chickens (n = 108) received test diets to which different amounts of PCBs (7 congeners) were added. The relationship between exposure time and accumulation of individual congeners in different chicken tissues, such as breast, thigh and abdominal fat tissue, was observed. In all tissues, the vast majority of the PCB accumulation occurred during the first 2 weeks of exposure. After that, PCB concentrations only increased in the abdominal fat tissue of the animals. The individual PCBs were distributed differently in the various tissues. While CBs 28, 118, 138, 153 and 180 accumulated in the chickens, CBs 52 and 101 were metabolized, but no methyl sulphone metabolites of these congeners could be detected. Our results provide information on the absorption, tissue distribution and biotransformation of the individual PCB congeners and confirm the structure–activity relationships for metabolism of PCBs in birds, which are different from those in fish or mammalian species. |
| Databáze: | OpenAIRE |
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