STATINS AND URSODEOXYCHOLIC ACID: COOPERATION OR NEUTRALITY?

Autor: Y. M. Pozdnyakov, I. N. Grigorieva
Rok vydání: 2009
Předmět:
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Statin
medicine.drug_class
medicine.medical_treatment
RM1-950
Disease
digestive system
Gastroenterology
statins
статины
Internal medicine
гиперхолестеринемия
medicine
Diseases of the circulatory (Cardiovascular) system
желчнокаменная болезнь
Pharmacology (medical)
In patient
hypercholesterolemia
business.industry
lcsh:RM1-950
Fatty liver
non-alcoholic fatty liver disease
nutritional and metabolic diseases
medicine.disease
digestive system diseases
Ursodeoxycholic acid
ursodeoxycholic acid
неалкогольная жировая болезнь печени
lcsh:Therapeutics. Pharmacology
lcsh:RC666-701
RC666-701
gallstone disease
Combined therapy
lipids (amino acids
peptides
and proteins)
non-alcoholic steatohepatitis
Therapeutics. Pharmacology
sense organs
урсодезоксихолевая кислота
Steatohepatitis
Cardiology and Cardiovascular Medicine
business
Adjuvant
неалкогольный стеатогепатит
medicine.drug
Zdroj: Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 5, Iss 6, Pp 51-54 (2016)
ISSN: 2225-3653
1819-6446
Popis: Results of combined therapy of gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and hypercholesterolemia (HCE) with statins and ursodeoxycholic acid (UDCA) are analyzed. In GSD statin therapy was often accompanied with reduction of bile lithogenicity but did not always accelerate stone litholysis under their combination with UDCA. Statin induced liver injuries are often observed in NAFLD and NASH, adjuvant UDCA therapy shown positive effect on inflammatory and histological liver parameters in these diseases. Serum lipid levels in patients with HCE were reduced most effectively with statin combined with UDCA. Combined therapy with statin and UDCA is recommended in patient with HCE and chronic liver diseases.
Databáze: OpenAIRE
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