Different Efficiency of Liposomal Forms with Hydrophilic and Hydrophobic Antitumor Agents in Relation to Solid Transplants of Mouse Tumor and Its Metastases in the Liver
| Autor: | L. A. Bogdanova, Nelly A. Popova, V. I. Kaledin, T. S. Morozkova, Valery P. Nikolin, Yu. V. Tornuev |
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| Rok vydání: | 2015 |
| Předmět: |
Cycloplatam
Pathology medicine.medical_specialty Organoplatinum Compounds Antineoplastic Agents Pharmacology 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine Drug Delivery Systems Cell Line Tumor medicine Animals Mouse tumor Solid tumor Physiological saline Liposome Muscle Neoplasms Chemistry Hydrophobic drug Liver Neoplasms General Medicine Survival Analysis Treatment Outcome Injections Intravenous Liposomes Nitrogen Mustard Compounds High incidence Corticosterone 030217 neurology & neurosurgery Injections Intraperitoneal Neoplasm Transplantation Hormone |
| Zdroj: | Bulletin of experimental biology and medicine. 161(6) |
| ISSN: | 1573-8221 |
| Popis: | Experiments were performed on the model of transplanted mouse tumor with high incidence of liver metastases. Hydrophilic drug cycloplatam (injected intravenously in liposomes) was more potent than “free cycloplatam” (injected intravenously or intraperitoneally in physiological saline) in inhibiting the growth of natural and experimental metastases in the liver. By contrast, liposomal cycloplatam had lower efficiency than free cycloplatam in suppressing the growth of solid tumor. Liposomal and free cortifen (hydrophobic hormonal cytostatic) produced nearly the same effects on solid tumor growth. Our results suggest that liposomal forms of hydrophobic compounds producing nonselective effect on tumor cells (e.g., actinomycin D or Cosmegen), should not have advantages over free forms. |
| Databáze: | OpenAIRE |
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