Associations of Prenatal Exposure to Organophosphate Pesticide Metabolites with Gestational Age and Birth Weight

Autor:	Joseph M. Braun, Stephen Rauch, Kimberly Yolton, Jane Khoury, Antonia M. Calafat, Bruce P. Lanphear, M. Angela Montesano, Dana B. Barr
Rok vydání:	2012
Předmět:	Adult medicine.medical_specialty prenatal organophosphate Health Toxicology and Mutagenesis Urinary system Birth weight Gestational Age 010501 environmental sciences 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Organophosphorus Compounds paraoxanase Pregnancy Humans DAPs Medicine Pesticides pesticide 030304 developmental biology 0105 earth and related environmental sciences 2. Zero hunger 0303 health sciences PON business.industry Obstetrics Research Organophosphate Infant Newborn Public Health Environmental and Occupational Health birth weight toxicity Gestational age medicine.disease OPs Confidence interval 3. Good health chemistry Maternal Exposure Cohort Gestation Female business fetal growth
Zdroj:	Environmental Health Perspectives
ISSN:	1552-9924 0091-6765
Popis:	Background: Prenatal exposure to organophosphate (OP) insecticides, a widely used class of pesticides, may be associated with decreased gestational age and lower birth weight. Single nucleotide polymorphisms in paroxanase (PON1) enzyme genotypes may modify the relationships between OP exposure and perinatal outcomes. Objective: We examined the relationship of prenatal OP insecticide exposure, measured using urinary dialkyl phosphate (DAP) metabolite concentrations, with gestational age and birth weight. Methods: We measured the concentrations of six nonspecific DAP metabolites of OP insecticides in two maternal spot urine samples collected in a prospective birth cohort. We performed multivariable regression to examine associations between the sum of six DAP concentrations (ΣDAP) with gestational age and birth weight. We also examined whether these associations differed according to infant PON1192 and PON1–108 genotypes. Results: Among 306 mother–infant dyads, a 10-fold increase in ΣDAP concentrations was associated with a decrease in covariate-adjusted gestational age [–0.5 weeks; 95% confidence interval (CI): –0.8, –0.1] and birth weight (–151 g; CI: –287, –16); the decrements in birth weight were attenuated after adjusting for gestational age. The relationship between ΣDAP concentrations and gestational age was stronger for white (–0.7 weeks; CI: –1.1, –0.3) than for black (–0.1 weeks; 95% CI: –0.9, 0.6) newborns. In contrast, there was a greater decrease in birth weight with increasing urinary ΣDAP concentrations for black (–188 g; CI: –395, 19) than for white (–118 g; CI: –296, 60) newborns. Decrements in birth weight and gestational age associated with ΣDAP concentrations were greatest among infants with PON1192QR and PON–108CT genotypes. Conclusions: Prenatal urinary ΣDAP concentrations were associated with shortened gestation and reduced birth weight in this cohort, but the effects differed by race/ethnicity and PON1192/108 genotypes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1e2f16d89956836d161d9330c9440d https://doi.org/10.1289/ehp.1104615 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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