Leishmania (Viannia) naiffi: rare enough to be neglected?
| Autor: | Adriano Gomes-Silva, Ellen Priscila Gadelha Yamashita, Alda Maria Da-Cruz, Jorge Augusto de Oliveira Guerra, Gustavo Adolfo Sierra Romero, Elisa Cupolillo, Giselle Aparecida Fagundes-Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology Enzimas Remission Spontaneous lcsh:QR1-502 clinical outcome lcsh:Microbiology Common species Leishmania (Viannia) naiffi Amazon Region Treatment Failure Leishmaniasis Skin Leishmania biology Geography Clinical course Middle Aged Response to treatment Amazônia therapeutic failure Brazil medicine.drug Microbiology (medical) Adult Electrophoresis medicine.medical_specialty Rainforest lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Short Communication Antiprotozoal Agents Young Adult Rare Diseases parasitic diseases medicine Leishmaniose Humans In patient Pentamidine Demography Population Density multilocus enzyme electrophoresis biology.organism_classification Antimony Sodium Gluconate Immunology Antimonial |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 110, Iss 6, Pp 797-800 (2015) Memórias do Instituto Oswaldo Cruz Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB Memórias do Instituto Oswaldo Cruz, Volume: 110, Issue: 6, Pages: 797-800, Published: SEP 2015 |
| ISSN: | 1678-8060 |
| Popis: | In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmania species. Few reports of Leishmania (Viannia) naiffi infection suggest that its occurrence is uncommon and the reported cases present a benign clinical course and a good response to treatment. This study aimed to strengthen the clinical and epidemiological importance of L. (V.) naiffi in the Amazon Region (Manaus, state of Amazonas) and to report therapeutic failure in patients infected with this species. Thirty Leishmania spp samples isolated from cutaneous lesions were characterised by multilocus enzyme electrophoresis. As expected, the most common species was Leishmania (V.) guyanensis (20 cases). However, a relevant number of L. (V.) naiffi patients (8 cases) was observed, thus demonstrating that this species is not uncommon in the region. No patient infected with L. (V.) naiffi evolved to spontaneous cure until the start of treatment, which indicated that this species may not have a self-limiting nature. In addition, two of the patients experienced a poor response to antimonial or pentamidine therapy. Thus, either ATL cases due to L. (V.) naiffi cannot be as uncommon as previously thought or this species is currently expanding in this region. |
| Databáze: | OpenAIRE |
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