Late recurrence of herpes simplex virus meningoencephalitis in two infants
| Autor: | Paraskevas Koutsovitis, Sotiris Youroukos, Tania Siahanidou, Dimitris Anagnostakis, Helen Mandyla |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pediatrics
medicine.medical_specialty Time Factors viruses Acyclovir medicine.disease_cause Antiviral Agents Polymerase Chain Reaction Virus Herpesviridae Recurrence Alphaherpesvirinae medicine Humans Simplexvirus Aciclovir biology business.industry Infant Newborn Meningoencephalitis Electroencephalography medicine.disease biology.organism_classification Herpes simplex virus Pediatrics Perinatology and Child Health Immunology Encephalitis Female Encephalitis Herpes Simplex Viral disease business Injections Intraperitoneal medicine.drug |
| Zdroj: | European Journal of Pediatrics. 160:732-735 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s004310100848 |
| Popis: | Two infants with recurrence of herpes simplex virus (HSV) encephalitis are reported. Both patients developed HSV encephalitis during their neonatal period and were treated with iv acyclovir. Long-term oral acyclovir prophylaxis was given thereafter. At the age of 8 and 11 months respectively, both babies, while under oral acyclovir prophylaxis, presented a second episode of HSV encephalitis. An inadequate dose of suppressive oral acyclovir therapy may be responsible for the recurrence of encephalitis in these two babies. Conclusion: the present observations emphasise the need for very long follow-up of any infant who has suffered from neonatal herpes simplex virus encephalitis and the need for careful prospective controlled studies in order to define the appropriate treatment regimen (initial plus prophylaxis) for neonates with herpes simplex virus infections. |
| Databáze: | OpenAIRE |
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