Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat
| Autor: | Betina Elfving, Heidi Kaastrup Müller, Kristoffer Højgaard, Oskar Hougaard Jefsen, David J. Nutt, Sofie Laage Christiansen, Gregers Wegener |
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| Rok vydání: | 2019 |
| Předmět: |
Hallucinogen
Male medicine.medical_treatment Pharmacology Motor Activity Open field Psilocybin antidepressive agents 03 medical and health sciences 0302 clinical medicine Animal models of depression medicine Animals psilocybin Biological Psychiatry Serotonin receptor agonist Behavior Animal business.industry Depression preclinical drug evaluation Antidepressive Agents 030227 psychiatry Rats Stimulant Psychiatry and Mental health Disease Models Animal Psilocin hallucinogens business 030217 neurology & neurosurgery medicine.drug Behavioural despair test |
| Zdroj: | Jefsen, O, Højgaard, K, Christiansen, S L, Elfving, B, Nutt, D J, Wegener, G & Müller, H K 2019, ' Psilocybin lacks antidepressant-like effect in the Flinders Sensitive Line rat ', Acta Neuropsychiatrica, vol. 31, no. 4, pp. 213-219 . https://doi.org/10.1017/neu.2019.15 |
| ISSN: | 1601-5215 0924-2708 |
| DOI: | 10.1017/neu.2019.15 |
| Popis: | Objective:Psilocybin is a serotonin receptor agonist with a therapeutic potential for treatment-resistant depression and other psychiatric illnesses. We investigated whether the administration of psilocybin had an antidepressant-like effect in a rat model of depression.Methods:Using the Flinders Sensitive Line (FSL) rat model of depression, we assessed the antidepressant-like effect of psilocin and psilocybin, measured as a reduction in immobility time in the forced swim test (FST). We measured locomotor activity in an open field test (OFT) to control for stimulant properties of the drugs. We performed a set of experiments to test different doses, treatment paradigms, and timing of the tests in relation to the drug administration.Results:Psilocin and psilocybin showed no effect on immobility, struggling, or swimming behaviour in the FST and no effect on locomotor activity in the OFT. FSL rats did show significantly more immobility than their control strain, the Flinders Resistant Line, as expected.Conclusion:Psilocin and psilocybin showed no antidepressant-like effect in the FSL rats, despite a positive effect in humans. This suggests that other animal models of depression and other behavioural tests may be more appropriate for translational studies in the effects of psilocybin. |
| Databáze: | OpenAIRE |
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