Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity
| Autor: | Jin-A Lee, Yong Sook Goo, Anna Jo, Jun-Young Oh, Ara Kwon, Hoon Kim, Hyong Kyu Kim |
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| Rok vydání: | 2013 |
| Předmět: |
Inclusion Bodies
Dendritic spike Kinesins Colocalization Nonsynaptic plasticity Nerve Tissue Proteins Dendrites Cell Biology Biology Actin cytoskeleton Actins Rats Cell biology Actin Cytoskeleton Protein Biosynthesis Actin-Related Protein 2 Synaptic plasticity P-bodies Animals Premovement neuronal activity Kinesin RNA Messenger |
| Zdroj: | Journal of Cell Science. |
| ISSN: | 1477-9137 0021-9533 |
| DOI: | 10.1242/jcs.125690 |
| Popis: | In neurons, transport of a subset of mRNAs to subcellular regions and their translation has a role in synaptic plasticity. Recent studies have suggested a control mechanism of this local translation through mRNA compartmentalization or degradation. Here we report that processing bodies (P-bodies), which are involved in mRNA degradation or storage, are transported to dendrites by conventional kinesin (KIF5A) as a motor protein. Neuronal activation induced by depolarization increased the co-localization of P-bodies with PSD-95 in dendrites. This neuronal activity increased the release of Nd1 and Arp2 mRNA from the P-bodies, and consequently reversed the decrease of F-actin, induced by overexpression of Dcp1a, in the dendrites. Our data suggest that the activity-induced redistribution of P-bodies and mRNA release from P-bodies may have a role in synaptic structural plasticity by altering levels of mRNAs, which are involved in the dynamics of the actin cytoskeleton in dendrites. |
| Databáze: | OpenAIRE |
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