Uptake of labelled noradrenaline by isolated atria
| Autor: | J. H. Burn, G. P. Burn |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.medical_specialty
Tyramine Norepinephrine (medication) chemistry.chemical_compound Norepinephrine Cocaine Internal medicine medicine Extracellular Animals Norepinephrine metabolism Heart Atria Chemistry Myocardium Research Myocardium metabolism General Medicine Articles Endocrinology Atrial rate cardiovascular system Outflow Rabbits Extracellular Space Intracellular medicine.drug |
| Zdroj: | British journal of pharmacology and chemotherapy. 16 |
| ISSN: | 0366-0826 |
| Popis: | The uptake of labelled noradrenaline by isolated rabbit atria has been studied, and the rate of outflow of radioactivity after a period of loading has been recorded. There is first a rapid outflow presumably from extracellular space, followed by a slow outflow presumably from intracellular space. Cocaine greatly diminished the intracellular uptake. Tyramine caused an increased outflow of radioactivity from intracellular sites which was not due to the increase in atrial rate, since noradrenaline which increased the rate more than tyramine had less effect on the outflow. |
| Databáze: | OpenAIRE |
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