High level of γH2AX phosphorylation in the cord-blood cells of large-for-gestational-age (LGA) newborns

Autor:	Roberto Scarpato, Valentina Colosimo, Anna Chiaramonte, Domenica Di Bello, Veronica Esposti, Aurora Falaschi, Paolo Ghirri, Consuelo Micheli, Serena Testi
Rok vydání:	2022
Předmět:	Blood Cells Pregnancy Placenta Health Toxicology and Mutagenesis Infant Small for Gestational Age Infant Newborn Genetics Birth Weight Humans Infant Female Phosphorylation
Zdroj:	Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 881:503526
ISSN:	1383-5718
DOI:	10.1016/j.mrgentox.2022.503526
Popis:	Newborns can experience adverse effects as a consequence of maternal or in utero exposure, altered growth of the fetus, or placental dysfunctions. Accurate characterization of gestational age allows monitoring of fetal growth, identification of deviations from the normal growth trajectory, and classification of babies as adapted, small, or large for gestational age (AGA, SGA, or LGA). The aim of this work was to evaluate nuclear and oxidative damage in umbilical cord-blood cells of newborns (sampled at birth), by applying the γH2AX assay and the fluorescent probe BODIPY
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc132cd9f9e338feb3dba830ea6e619e https://doi.org/10.1016/j.mrgentox.2022.503526 Zobrazit plný text záznamu Full Text from ScienceDirect