Selenium, zinc, and copper changes with valproic acid: Possible relation to drug side effects
| Autor: | B. J. Wilder, H.A. Van Rinsvelt, R.W. Hurd, L. De Reu, B. Karas, Willy Maenhaut |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Valproic Acid
medicine.medical_treatment food and beverages chemistry.chemical_element Rats Inbred Strains Zinc Pharmacology Copper Rats Fully developed Selenium Anticonvulsant chemistry medicine Animals Drug side effects lipids (amino acids peptides and proteins) Trace metal Neurology (clinical) medicine.drug |
| Zdroj: | Neurology. 34:1393-1393 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.34.10.1393 |
| Popis: | Side effects of treatment with the anticonvulsant valproic acid (VPA) suggested the possibility of alteration of trace metal status. Administration of VPA for 1 week produced significant depletion of zinc and selenium in plasma of rats and a one-third reduction of hepatic selenium. Patients who were treated chronically, with VPA as the sole anticonvulsant medication, had decreased plasma selenium levels. Most cases of VPA-associated hepatotoxicity occur in children. This could be due to decreased selenium concentrations when mechanisms for protection against peroxidative damage are not fully developed. |
| Databáze: | OpenAIRE |
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