Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture
| Autor: | Mukaddes Esrefoglu, Sertac Aksakalli, Ahmet Hüseyin Acar, Muhammet Birlik, Hakki Oguz Kazancioglu, Seref Ezirganli |
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| Přispěvatelé: | EŞREFOĞLU, MUKADDES |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Palate Hard Palatal Expansion Technique Time Factors Narrow maxilla medicine.medical_treatment Intraperitoneal injection education Pharmaceutical Science Dentistry midpalatal suture Rats Sprague-Dawley chemistry.chemical_compound Caffeic Acids Suture (anatomy) Osteogenesis Drug Discovery medicine Caffeic acid Animals Rapid maxillary expansion Bone formation Midpalatal suture Caffeic acid phenethyl ester Original Research bone formation caffeic acid phenethyl ester Pharmacology Drug Design Development and Therapy business.industry KAZANCIOGLU H. AKSAKALLI S. EZIRGANLI S. BIRLIK M. Esrefoglu M. ACAR A. -Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture.- Drug design development and therapy cilt.9 ss.6483-8 2015 Phenylethyl Alcohol chemistry rapid maxillary expansion histopathology business Injections Intraperitoneal |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| Popis: | Hakki Oguz Kazancioglu,1 Sertac Aksakalli,2 Seref Ezirganli,1 Muhammet Birlik,2 Mukaddes Esrefoglu,3 Ahmet Hüseyin Acar1 1Department of Oral and Maxillofacial Surgery, 2Department of Orthodontics, Faculty of Dentistry, 3Department of Histology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey Background: Narrow maxilla is a common problem in orthodontics and dentofacial orthopedics. To solve this problem, a procedure called rapid maxillary expansion (RME) has been used. However, relapse tendency is a major problem of RME. Although relapse tendency is not clearly understood, various treatment procedures and new application has been investigated. The present study aimed to investigate the possible effectiveness of caffeic acid phenethyl ester (CAPE) on new bone formation in rat midpalatal suture after RME.Materials and methods: Twenty male Sprague Dawley rats were used in this study. The animals were randomly divided into two groups as control and CAPE group. In CAPE group, CAPE was administered systemically via intraperitoneal injection. RME procedure was performedon all animals. For this purpose, the springs were placed on the maxillary incisors of rats and activated for 5 days. After then, the springs were removed and replaced with short lengths of rectangular retaining wire for consolidation period of 15 days. At the end of the study, histomorphometric analysis was carried out to assess of new bone formation.Results: New bone formation was significantly greater in CAPE group than the control group (P |
| Databáze: | OpenAIRE |
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