A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis
| Autor: | Kouichi Yamamura, Taku Oikawa, Yuki Fujimoto, Shiro Mizuno, Kazuaki Nishiki, Takashi Sakuma, Kazuhiro Osanai, Rieko Oikawa, Yoshimichi Ueda, Shohei Shinomiya, Yutaka Takahara, Ryo Kato, Keisuke Nakase, Saki Matsuura, Masafumi Nojiri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Metastatic lesions Case Report Osteoblastic bone metastases 03 medical and health sciences 0302 clinical medicine ROS1-Rearranged lung adenocarcinoma medicine ROS1 Lung cancer lcsh:RC705-779 Lung Crizotinib business.industry Transbronchial lung biopsy Bone metastasis lcsh:Diseases of the respiratory system respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure 030228 respiratory system 030220 oncology & carcinogenesis Adenocarcinoma business medicine.drug |
| Zdroj: | Respiratory Medicine Case Reports Respiratory Medicine Case Reports, Vol 30, Iss, Pp 101124-(2020) |
| ISSN: | 2213-0071 |
| Popis: | A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer. |
| Databáze: | OpenAIRE |
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