Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
| Autor: | Chasen J. Greig, Lucy Zhang, Robert A. Cowles |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Short Bowel Syndrome medicine.medical_specialty Time Factors Peanut butter Crypt Administration Oral Citalopram Enteral administration Gastroenterology Mice 03 medical and health sciences 0302 clinical medicine Intestinal mucosa Ileum Internal medicine mental disorders medicine Animals Humans Intestinal Mucosa Cell Proliferation business.industry digestive oral and skin physiology Short bowel syndrome medicine.disease Mucosal growth Mice Inbred C57BL 030220 oncology & carcinogenesis Models Animal Female 030211 gastroenterology & hepatology Surgery Intestinal Disorder business Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Journal of Surgical Research. 236:326-331 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/j.jss.2018.11.033 |
| Popis: | Parenterally administered selective serotonin reuptake inhibitors, such as citalopram, increase intestinal mucosal absorptive surface by day 7 of treatment. We hypothesized that enteral citalopram would also induce intestinal mucosal growth, thus allowing for therapy with an oral agent.Following a habituation period, C57BL/6 mice received peanut butter pellets containing 10, 50, or 100 mg/kg/d citalopram for 7 d (n = 5); or 25 mg/kg/d citalopram for 14 (n = 3) or 21 (n = 5) d; or plain peanut butter pellets for 7 (n = 2), 14 (n = 2), or 21 d (n = 3). Two-centimeter ileal segments were harvested and prepared for microscopic assessment of villus height (VH), crypt depth, villus width (VW), and crypt width. Mucosal surface area (MSA) was calculated and data were compared using Student's t-test.Enteral administration of citalopram had virtually no effect on VH, VW, or crypt depth after 7 d; crypt width decreased significantly (P value range 0.0002 to0.0001), likely contributing to the increases in MSA (P value range 0.0578 to 0.0006). After 14 d of treatment, citalopram significantly increased VH (P 0.0001), VW (P = 0.0058), and ileal MSA per mmEnteral citalopram given for 14 d results in increased VH and ileal MSA, which remains increased by day 21. Selective serotonin reuptake inhibitors show potential as oral therapy for serious intestinal disorders such as short bowel syndrome. |
| Databáze: | OpenAIRE |
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