Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases
| Autor: | Jorge Sequeiros, Ana Ramires, Ângela Leite, Susana Lêdo, Maria Alzira Pimenta Dinis |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Longitudinal study Late onset Genetic Counseling Disease 030105 genetics & heredity Anxiety 03 medical and health sciences Psychoticism Genetics medicine Humans Genetic Testing Genetics (clinical) Genetic testing Aged Amyloid Neuropathies Familial medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Factitious Disorders Huntington Disease Asymptomatic Diseases Female medicine.symptom business Somatization Clinical psychology Psychopathology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1878-0849 |
| Popis: | This longitudinal study aimed at determining predicting variables for middle and long-term psychological disturbance due pre-symptomatic testing (PST) for two late-onset neurological diseases, Huntington disease (HD) and TTR (transthyretin protein) familial amyloid polyneuropathy (FAP) Val30Met (now classified as Val50Met). 196 clinical records of persons who performed PST at least three years ago and answered to the two stages of evaluation (before PST and least 3 years after disclosure of results) were analysed. For this purpose, regression analysis was performed, showing that the Positive Symptom Distress Index (PSDI), psychoticism, somatization and paranoid ideation dimensions assume predictive value in the middle and long-term impact for total anxiety and PSDI. The result of PST was not a relevant predictor. The application of an evaluation instrument of various psychopathological dimensions played a fundamental role in the detection of clinical situations that may arise several years later after PST. Attention should be paid to providing psychological support to persons at-risk who, at the pre-test phase, present some psychopathology indices before pursuing with genetic testing. |
| Databáze: | OpenAIRE |
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