Correlation Between E6 and E7 Oncogenes and Malignant Transformation of Laryngeal Papillomatosis (LP) with Human Papillomavirus (HPV) in Pediatric Population
| Autor: | Ruchi Mangal, Zaid Khreefa, Richard Felix, Vivian Isaac, Pheven Dereje, Khairya A Fatouh, Bahig M. Shehata, Wasim Selwanes, Janet Poulik |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Papillomavirus E7 Proteins 030105 genetics & heredity Alphapapillomavirus Pathology and Forensic Medicine Malignant transformation Correlation 03 medical and health sciences 0302 clinical medicine Genotype Medicine Neoplasm Humans Child Laryngeal Neoplasms Papillomaviridae 030219 obstetrics & reproductive medicine Oncogene Papilloma business.industry Papillomavirus Infections General Medicine Oncogene Proteins Viral Oncogenes medicine.disease Squamous carcinoma medicine.anatomical_structure Pediatrics Perinatology and Child Health Cancer research business Respiratory tract Laryngeal papillomatosis |
| Zdroj: | Fetal and pediatric pathology. 40(4) |
| ISSN: | 1551-3823 |
| Popis: | INTRODUCTION Laryngeal papillomatosis (LP) is the most common benign neoplasm affecting the upper respiratory tract mucosa in children. The most common genotypes of HPV associated with LP are types 6 and 11. Methods: Among 187 patients identified in our institution with LP, four cases showed malignant transformation to invasive squamous carcinoma. Results: These patients had tumors with HPV viruses that showed high expression of oncogene E6 and E7 and low expression of E2. Conclusion: Malignant transformation of LP is associated with oncogenic expression of E6 and E7. |
| Databáze: | OpenAIRE |
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