Hemodynamic aspects of Alzheimer's disease
| Autor: | Mika Sato, Yasushi Kondoh, Yasuhito Watahiki, Ken Nagata, Yuichi Satoh, Maki Sugawara, Sumie Leung, David W. Wright, Georgia A. Box, Eku Shimosegawa, Hiromichi Yuya |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Pathology Hemodynamics Models Biological General Biochemistry Genetics and Molecular Biology History and Philosophy of Science Alzheimer Disease Internal medicine medicine Animals Humans Vascular dementia Aged medicine.diagnostic_test Resting state fMRI General Neuroscience Dementia Vascular Brain Middle Aged medicine.disease Pathophysiology Functional imaging Cerebral blood flow Positron emission tomography Cerebrovascular Circulation Cardiology Psychology Energy Metabolism Perfusion Tomography Emission-Computed |
| Zdroj: | Annals of the New York Academy of Sciences. 977 |
| ISSN: | 0077-8923 |
| Popis: | Neuroradiological functional imaging techniques demonstrate the patterns of hypoperfusion and hypometabolism that are thought to be useful in the differential diagnosis of Alzheimer's disease (AD) from other dementing disorders. Besides the distribution patterns of perfusion or energy metabolism, vascular transit time (VTT), vascular reactivity (VR), and oxygen extraction fraction (OEF), which can be measured with positron emission tomography (PET), provide hemodynamic aspects of brain pathophysiology. In order to evaluate the hemodynamic features of AD, PET studies were carried out in 20 patients with probable AD and 20 patients with vascular dementia (VaD). The PET findings were not included in their diagnostic process of AD. Using oxygen-15-labeled compounds, cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO(2)), OEF, cerebral blood volume, and VTT were measured quantitatively during resting state. To evaluate VR, CBF was also measured during CO(2) inhalation. There was a significant increase in OEF in and around the parietotemporal cortices, but both VTT and VR were well preserved in patients with AD. By contrast, VR was markedly depressed and VTT was mildly prolonged in patients with VaD. Thus, from the hemodynamic point of view, the preservation of vascular reserve may be a distinct difference between AD and VaD. Furthermore, this indicates a hemodynamic integrity of the vasculature in the level of arterioles in AD. |
| Databáze: | OpenAIRE |
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