Combining Transcranial Magnetic Stimulation and Electroencephalography May Contribute to Assess the Severity of Alzheimer's Disease
| Autor: | Hilkka Soininen, Anne M. Jauhiainen, Petro Julkunen, Ari Pääkkönen, Mervi Könönen, Jari Karhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Aging
medicine.medical_specialty Article Subject Cognitive Neuroscience medicine.medical_treatment Disease Electroencephalography Audiology lcsh:Geriatrics behavioral disciplines and activities lcsh:RC321-571 Behavioral Neuroscience Cellular and Molecular Neuroscience Rating scale mental disorders Medicine Dementia Cognitive decline Psychiatry lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry medicine.diagnostic_test business.industry Small sample Control subjects medicine.disease Transcranial magnetic stimulation lcsh:RC952-954.6 Neurology Neurology (clinical) business Research Article |
| Zdroj: | International Journal of Alzheimer's Disease, Vol 2011 (2011) International Journal of Alzheimer's Disease |
| ISSN: | 2090-0252 |
| Popis: | Alzheimer's disease (AD) is the most common form of old age dementia, and mild cognitive impairment (MCI) often precedes AD. In our previous study (Julkunen et al. 2008), we found that the combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) was able to find distinct differences in AD and MCI patients as compared to controls. Here, we reanalyzed the small sample data from our previous study with the aim to test the sensitivity of the TMS-EEG characteristics to discriminate control subjects (n=4) from MCI (n=5) and AD (n=5) subjects. Furthermore, we investigated how the TMS-EEG response characteristics related to the scores of the dementia rating scales used to evaluate the severity of cognitive decline in these subjects. We found that the TMS-EEG response P30 amplitude correlated with cognitive decline and showed good specificity and sensitivity in identifying healthy subjects from those with MCI or AD. Given the small sample size, further studies may be needed to confirm the results. |
| Databáze: | OpenAIRE |
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