Expansion of unconventional T cells with natural killer markers in malaria patients
| Autor: | M.Kaiissar Mannor, Jun Kobayashi, Hiroho Sekikawa, Ramesh C. Halder, Chikako Miyaji, Hisami Watanabe, Sufi Reza M. Morshed, Hiromu Toma, Yoshiya Sato, Kuni Iwai, Sinichi Toyabe, Anura Weerasinghe, Hiroki Matsuoka, Toru Abo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Time Factors Adolescent Anemia T-Lymphocytes Plasmodium falciparum Antigens Protozoan Parasitemia Immunological memory Lymphocyte Activation Plasmodium CD57 Antigens T-Lymphocyte Subsets parasitic diseases medicine Malaria Vivax Animals Humans Malaria Falciparum Child biology Granulocytosis Middle Aged medicine.disease biology.organism_classification Virology CD56 Antigen Immunity Innate Killer Cells Natural Kinetics Infectious Diseases Child Preschool Immunology Antigens Surface Parasitology Female Early phase Plasmodium vivax Malaria γδt cells Biomarkers |
| Zdroj: | Parasitology international. 52(1) |
| ISSN: | 1383-5769 |
| Popis: | Immunological states during human malarial infection were examined. In parallel with parasitemia and anemia, granulocytosis was induced in the blood of patients, especially those infected with Plasmodium (P.) falciparum. At that time, the level of lymphocytes remained unchanged or slightly increased in the blood. However, the distribution of lymphocyte subsets was modulated, showing that the proportion of CD56(+)T cells, CD57(+)T cells, and gammadeltaT cells (i.e. all unconventional T cells) had increased in patients infected with P. falciparum or P. vivax. This phenomenon occurred at the early phase of infection and disappeared in the course of recovery. The data from patients with multiple attacks of P. vivax infection showed that there was no augmentation of these responses. In adult cases, the increase in the proportion of unconventional T cells seemed to closely parallel disease severity. However, all these responses were weak in children, even those infected with P. falciparum. In conjunction with accumulating evidence from mouse malaria experiments, the present results suggest that the immunological state induced by malarial infection might mainly be an event of unconventional T cells and that the immunological memory might not be long-lasting, possibly due to the properties of unconventional T cells. |
| Databáze: | OpenAIRE |
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