Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments
| Autor: | Samantha Nishimura, Pragya Goel, Dion Dickman, Karthik Chetlapalli, Xiling Li, Catherine Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
active zone Neurotransmission lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Postsynaptic potential homeostasis Active zone Neurotransmitter lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry synaptic plasticity neuromuscular junction Chemistry Glutamate receptor Long-term potentiation Brief Research Report 030104 developmental biology Cellular Neuroscience Synaptic plasticity Retrograde signaling Drosophila Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Cellular Neuroscience, Vol 14 (2020) Frontiers in Cellular Neuroscience |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2020.00196 |
| Popis: | Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously induces hypo-innervation on one target and hyper-innervation on the other. However, the expression mechanisms that achieve this exquisite target-specific homeostatic control remain enigmatic. Here, we identify the distinct target-specific homeostatic expression mechanisms. On the hypo-innervated target, an increase in postsynaptic glutamate receptor (GluR) abundance is sufficient to compensate for reduced innervation, without any apparent presynaptic adaptations. In contrast, a target-specific reduction in presynaptic neurotransmitter release probability is reflected by a decrease in active zone components restricted to terminals of hyper-innervated targets. Finally, loss of postsynaptic GluRs on one target induces a compartmentalized, homeostatic enhancement of presynaptic neurotransmitter release called presynaptic homeostatic potentiation (PHP) that can be precisely balanced with the adaptations required for both hypo- and hyper-innervation to maintain stable synaptic strength. Thus, distinct anterograde and retrograde signaling systems operate at pre- and post-synaptic compartments to enable target-specific, homeostatic control of neurotransmission. |
| Databáze: | OpenAIRE |
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