The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer’s Disease
| Autor: | Anna E. King, David D. Ward, Manuela Pietzuch, James C. Vickers |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Aging Brain activity and meditation Cognitive Neuroscience Review Disease lcsh:RC321-571 default mode network 03 medical and health sciences 0302 clinical medicine medicine Dementia ddc:610 lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Default mode network Cognitive reserve Resting state fMRI fMRI Human brain cognitive reserve medicine.disease BDNF 030104 developmental biology medicine.anatomical_structure Psychology Alzheimer’s disease Neuroscience APOE 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in aging neuroscience 11, 30 (2019). doi:10.3389/fnagi.2019.00030 Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 11 (2019) |
| ISSN: | 1663-4365 |
| Popis: | Magnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state functional MRI data, topological maps can be created to visualize changes in brain activity, as well as to represent and assess the structural and functional connections between different brain regions. Crucially, Alzheimer’s disease (AD) is associated with progressive loss in this connectivity, which is particularly evident within the default mode network. In this paper, we review the recent literature on how factors that are associated with risk of dementia may influence the organization of the brain network structures. In particular, we focus on cognitive reserve and the common genetic polymorphisms of APOE and BDNF Val66Met. |
| Databáze: | OpenAIRE |
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