Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area
| Autor: | Belen Benito, Pilar Roura, Josep Franch-Nadal, Josep M A Pepió, Antonio Rodriguez-Poncelas, Gabriel Coll-de-Tuero, Marc Saez, Manel Mata-Cases |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Ronyons -- Malalties Kidneys -- Diseases Renal function Type 2 diabetes Diabetic nephropathy lcsh:RC870-923 urologic and male genital diseases Gastroenterology Diabetis no-insulinodependent Albuminúria Internal medicine Diabetes mellitus Diabetic nephropathies medicine Prevalence Non-insulin-dependent diabetes Albuminuria Humans Renal Insufficiency Chronic Renal impairment Macrovascular disease Aged Retrospective Studies Aged 80 and over business.industry Mediterranean Region Nefropaties diabètiques Kidney disease Middle Aged lcsh:Diseases of the genitourinary system. Urology medicine.disease Endocrinology Cross-Sectional Studies Diabetes Mellitus Type 2 Nephrology Microalbuminuria Female medicine.symptom business Research Article Follow-Up Studies |
| Zdroj: | BMC Nephrology BMC Nephrology, 2012, vol. 13, núm. 87, p. 1-9 Articles publicats (D-CM) DUGiDocs – Universitat de Girona instname BMC Nephrology, Vol 13, Iss 1, p 87 (2012) Recercat. Dipósit de la Recerca de Catalunya Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 1471-2369 |
| Popis: | Background Kidney disease is associated with an increased total mortality and cardiovascular morbimortality in the general population and in patients with Type 2 diabetes. The aim of this study is to determine the prevalence of kidney disease and different types of renal disease in patients with type 2 diabetes (T2DM). Methods Cross-sectional study in a random sample of 2,642 T2DM patients cared for in primary care during 2007. Studied variables: demographic and clinical characteristics, pharmacological treatments and T2DM complications (diabetic foot, retinopathy, coronary heart disease and stroke). Variables of renal function were defined as follows: 1) Microalbuminuria: albumin excretion rate & 30 mg/g or 3.5 mg/mmol, 2) Macroalbuminuria: albumin excretion rate & 300 mg/g or 35 mg/mmol, 3) Kidney disease (KD): glomerular filtration rate according to Modification of Diet in Renal Disease < 60 ml/min/1.73 m2 and/or the presence of albuminuria, 4) Renal impairment (RI): glomerular filtration rate < 60 ml/min/1.73 m2, 5) Nonalbuminuric RI: glomerular filtration rate < 60 ml/min/1.73 m2 without albuminuria and, 5) Diabetic nephropathy (DN): macroalbuminuria or microalbuminuria plus diabetic retinopathy. Results The prevalence of different types of renal disease in patients was: 34.1% KD, 22.9% RI, 19.5% albuminuria and 16.4% diabetic nephropathy (DN). The prevalence of albuminuria without RI (13.5%) and nonalbuminuric RI (14.7%) was similar. After adjusting per age, BMI, cholesterol, blood pressure and macrovascular disease, RI was significantly associated with the female gender (OR 2.20; CI 95% 1.86–2.59), microvascular disease (OR 2.14; CI 95% 1.8–2.54) and insulin treatment (OR 1.82; CI 95% 1.39–2.38), and inversely associated with HbA1c (OR 0.85 for every 1% increase; CI 95% 0.80–0.91). Albuminuria without RI was inversely associated with the female gender (OR 0.27; CI 95% 0.21–0.35), duration of diabetes (OR 0.94 per year; CI 95% 0.91–0.97) and directly associated with HbA1c (OR 1.19 for every 1% increase; CI 95% 1.09–1.3). Conclusions One-third of the sample population in this study has KD. The presence or absence of albuminuria identifies two subgroups with different characteristics related to gender, the duration of diabetes and metabolic status of the patient. It is important to determine both albuminuria and GFR estimation to diagnose KD. |
| Databáze: | OpenAIRE |
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