Histologic and Immunohistologic Findings and Prognosis of 40 Cases of Gastric Large B-Cell Lymphoma
| Autor: | Masahiro Kikuchi, Kenji Kurihara, Koji Ikejiri, Toshihiro Udoh, Akinori Iwashita, Hidefumi Higashi, Morishige Takeshita |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphoma B-Cell Lymphoepithelial lesion Follicular lymphoma Pathology and Forensic Medicine Stomach Neoplasms hemic and lymphatic diseases medicine Humans B-cell lymphoma B cell Aged business.industry Lymphoma Non-Hodgkin Large cell Large-cell lymphoma MALT lymphoma Lymphoma B-Cell Marginal Zone Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Lymphoma medicine.anatomical_structure Female Neprilysin Surgery Lymphoma Large B-Cell Diffuse Anatomy business |
| Zdroj: | The American Journal of Surgical Pathology. 24:1641-1649 |
| ISSN: | 0147-5185 |
| Popis: | It has been considered that gastric large B cell lymphoma mainly consists of mucosa-associated lymphoid tissue lymphoma (MALToma) with large cell transformation. However, debate continues about the cell lineage. We analyzed 61 operated cases of gastric B cell lymphoma, mainly focusing on 40 cases of diffuse large cell lymphoma (DLCL). Immunohistologically, two cases were classified as CD10-positive follicular lymphoma, 19 cases were low-grade MALToma, 11 CD10-negative DLCL with a component of low-grade MALToma (high-grade MALToma), 12 CD10-positive DLCL, and 17 CD10-negative DLCL without MALToma (pure DLCL). Lymphoepithelial lesion (LEL) was found in all -cases of high-grade MALToma, and in eight of these its invasion was confined to the mucosa and submucosa. Expression of Bcl-6 was detected in two cases of high-grade MALToma. Only two cases of CD10-positive DLCL had large cell LEL, and seven cases showed tumor invasion beyond the submucosa. All 12 cases were positive for Bcl-6, and a delicate meshwork of CD35 (Ber-MAC-DRC)-positive follicular dendritic cells was detected in eight cases. Pure DLCL of all 17 cases reached the proper muscle layer or more, and expression of Bcl-6 was detected in 10 cases. For patients with pure DLCL, overall survival was significantly (p |
| Databáze: | OpenAIRE |
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