Importance of signal intensity on T1-weighted spin-echo sequence for the diagnosis of chronic cholesteatomatous otitis
| Autor: | Anne Charpiot, Aurélie Karch-Georges, Francis Veillon, Idir Djennaoui, Aina Venkatasamy, Deborah Moustin, Sophie Riehm |
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| Přispěvatelé: | Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine otorhinolaryngologic diseases medicine Humans Otitis 030223 otorhinolaryngology Sequence (medicine) Retrospective Studies medicine.diagnostic_test Cholesteatoma Middle Ear business.industry Cholesteatoma Magnetic resonance imaging General Medicine Gold standard (test) [PHYS.MECA]Physics [physics]/Mechanics [physics] medicine.disease Diffusion Magnetic Resonance Imaging Otorhinolaryngology 030220 oncology & carcinogenesis Spin echo medicine.symptom Signal intensity Nuclear medicine business |
| Zdroj: | European Archives of Oto-Rhino-Laryngology European Archives of Oto-Rhino-Laryngology, 2020, 277 (6), pp.1601-1608. ⟨10.1007/s00405-020-05854-7⟩ |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/s00405-020-05854-7⟩ |
| Popis: | Number: 6 PMID: 32072243; OBJECTIVE: The aim of our study was to evaluate the importance of a non-injected T1-weighted spin-echo sequence (T1WSE) combined with a non-echo-planar diffusion-weighted (non-EPDW) sequence for the pre-operative detection of cholesteatoma by the radiologist on MRI, compared to surgery. MATERIALS AND METHODS: In this retrospective case review, 113 patients with chronic otitis underwent surgery (gold standard) for a clinical suspicion of cholesteatoma. Our primary outcome was to compare non-EPDW images + a contrast-free T1WSE sequence for cholesteatoma detection. Our secondary outcome was to quantify the signal intensity value of the suspected lesions, relative to the signal intensity of the cerebellum (Sic) to calculate Signal Intensity Ratios (SIR = SI/Sic). The SIR values of cholesteatomatous and non-cholesteatomatous tissue were compared to surgical findings. Receiver-operating characteristic curve analysis determined an optimum SIR cut-off value for the prediction of cholesteatoma. RESULTS: The sensitivity (96.9%) of non-EPDW for the diagnosis of cholesteatoma was high, with good specificity (74.2%), and increased to 85.5% when combined to a T1WSE sequence. Additionally, the mean SIR values (on T1WSE) of cholesteatoma were significantly lower than non-cholesteatomatous tissue (p 90%) and reduces risks of false-positive cases for surgeons. |
| Databáze: | OpenAIRE |
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