Pathological alterations typical of human Tay-Sachs disease, in the retina of a deep-sea fish
| Autor: | Lev Fishelson, Bella S. Galil, Yacov Delarea |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Mitochondrion
Biology Retina Retinal Rod Photoreceptor Cells biology.animal Deep sea fish medicine Animals Humans Seawater Gene Ecology Evolution Behavior and Systematics Tay-Sachs Disease Phylogenetic tree fungi Tay-Sachs disease Fishes Genetic disorder Vertebrate Intracellular Membranes General Medicine Anatomy medicine.disease Biological Evolution Mitochondria Cell biology medicine.anatomical_structure sense organs |
| Zdroj: | Naturwissenschaften. 87:363-365 |
| ISSN: | 1432-1904 0028-1042 |
| DOI: | 10.1007/s001140050741 |
| Popis: | Micrographs of retinas from the deep-sea fish Cataetyx laticeps revealed visual cells containing membranous whorls in the ellipsoids of the inner segments resulting from stretching and modifications of the mitochondria membranes and their cristae. These pathological structures seem to be homologous to the whorls observed in retinas of human carriers of Tay-Sachs disease. This disease, a genetic disorder, is found in humans and some mammals. Our findings in fish suggest that the gene responsible can be found throughout the vertebrate evolutionary tree, possibly dormant in most taxa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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