Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise
| Autor: | Natia Peradze, Ioannis G. Fatouros, Christos S. Mantzoros, Dimitrios Draganidis, Vassilis Mougios, Nikolaos Perakakis, Aikaterina Siopi, Wael Ghaly |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Aging Follistatin endocrine system medicine.medical_specialty Follistatin-Related Proteins Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Physiology 030209 endocrinology & metabolism Context (language use) Myostatin Biochemistry Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Humans Medicine Exercise physiology Exercise Clinical Research Articles Adiposity Aged Anthropometry biology business.industry Biochemistry (medical) VO2 max 030229 sport sciences Middle Aged medicine.disease Activins Blood pressure Physical Fitness embryonic structures Body Composition biology.protein Sedentary Behavior Metabolic syndrome business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 103:3890-3899 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2018-01056 |
| Popis: | CONTEXT: Clinical trials are evaluating the efficacy of inhibitors of the myostatin pathway in neuromuscular and metabolic diseases. Activins and follistatins are major regulators of the myostatin pathway, but their physiology in relation to metabolic and anthropometric variables and in response to exercise remains to be fully elucidated in humans. OBJECTIVE: We investigated whether concentrations of circulating activin A, activin B, follistatin, and follistatin-like 3 (FSTL3) are associated with anthropometric and metabolic variables and whether they are affected by exercise. DESIGN: Activin A, activin B, follistatin, and FSTL3 were measured in (1) 80 subjects divided according to age (young vs old) and fitness status (active vs sedentary) before and after exercise at 70% maximal oxygen consumption (VO(2)max), followed by 90% of VO(2)max until exhaustion; and (2) 23 subjects [9 healthy and 14 with metabolic syndrome (MetS)] who completed four sessions: no exercise, high-intensity interval exercise, continuous moderate-intensity exercise, and resistance exercise for up to 45 minutes. RESULTS: At baseline, follistatin and FSTL3 concentrations were positively associated with age, fat percentage, and body mass index (P < 0.001). Follistatin was positively associated with serum cholesterol (P = 0.005), low-density lipoprotein cholesterol (P = 0.01), triglycerides (P = 0.033), and blood pressure (P = 0.019), whereas activin A and activin B were higher in physically active participants (P = 0.056 and 0.029, respectively). All exercise types increased the levels of all hormones ∼10% to 21% (P = 0.034 for activin B, P < 0.001 for the others) independent of the presence of MetS. CONCLUSION: Concentrations of circulating activins and follistatins are associated with metabolic parameters and increase after 45 minutes of exercise. |
| Databáze: | OpenAIRE |
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