Multidrug resistance genes in staphylococci from animals that confer resistance to critically and highly important antimicrobial agents in human medicine
| Autor: | Congming Wu, Andrea T. Feßler, Beibei Li, Yang Wang, Jianzhong Shen, Sarah Wendlandt, Wan Jiang Zhang, Stefan Schwarz, Kristina Kadlec |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Transposable element Staphylococcus Staphylococcal Infections Biology Antimicrobial Microbiology Anti-Bacterial Agents Multiple drug resistance Infectious Diseases Plasmid Antibiotic resistance Bacterial Proteins Drug Resistance Multiple Bacterial Virology Animals Humans ATP-Binding Cassette Transporters Efflux Mobile genetic elements Gene |
| Zdroj: | Trends in Microbiology. 23:44-54 |
| ISSN: | 0966-842X |
| DOI: | 10.1016/j.tim.2014.10.002 |
| Popis: | Most antimicrobial resistance genes known so far to occur in staphylococci of animal origin confer resistance to a specific class of antimicrobial agents or to selected members within such a class. However, there are also a few examples of multidrug resistance (MDR) genes that confer resistance to antimicrobial agents of different classes by either target site methylation or active efflux via ATP-binding cassette (ABC) transporters. The present review provides an overview of these MDR genes with particular reference to those genes involved in resistance to critically or highly important antimicrobial agents used in human and veterinary medicine. Moreover, their location on mobile genetic elements and colocated resistance genes, which may play a role in coselection and persistence of the MDR genes, are addressed. |
| Databáze: | OpenAIRE |
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