A community-based RCT for oral cancer screening with toluidine blue
| Autor: | William Wang Yu Su, Sherry Yueh Hsia Chiu, Tony Hsiu Hsi Chen, Amy Ming Fang Yen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Dentistry Oral Submucous Fibrosis law.invention Young Adult Randomized controlled trial law Internal medicine medicine Confidence Intervals Humans Mass Screening Tolonium Chloride Young adult Coloring Agents General Dentistry Areca Early Detection of Cancer Leukoplakia Aged Aged 80 and over Chi-Square Distribution business.industry Incidence (epidemiology) Smoking Cancer Middle Aged medicine.disease Cancer registry Oral submucous fibrosis Mouth Neoplasms Leukoplakia Oral business Chi-squared distribution Precancerous Conditions |
| Zdroj: | Journal of dental research. 89(9) |
| ISSN: | 1544-0591 |
| Popis: | Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10−5) was non-significantly 21% lower than that in the control group (35.4 x 10−5). |
| Databáze: | OpenAIRE |
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