Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
| Autor: | Steven M. Paul, Douglas F. Covey, Charles F. Zorumski, Steven Mennerick |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Neuroactive steroid
Physiology medicine.drug_class Steroid enantiomers Allopregnanolone Biochemistry Anxiolytic Article lcsh:RC346-429 lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology SGE-217 mental disorders medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Molecular Biology Brexanolone lcsh:Neurology. Diseases of the nervous system Endocrine and Autonomic Systems business.industry GABAA receptor lcsh:QP351-495 medicine.disease Tonic inhibition 030227 psychiatry lcsh:Neurophysiology and neuropsychology Mood nervous system chemistry Major depressive disorder Anxiety Antidepressant medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Stress, Vol 11, Iss, Pp-(2019) Neurobiology of Stress |
| ISSN: | 2352-2895 |
| DOI: | 10.1016/j.ynstr.2019.100196 |
| Popis: | The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the hope of a new era in treating mood and anxiety disorders based on the potential of neurosteroids as modulators of brain function. This review considers potential mechanisms contributing to antidepressant and anxiolytic effects of allopregnanolone and other GABAergic neurosteroids focusing on their actions as positive allosteric modulators of GABAA receptors. We also consider their roles as endogenous “stress” modulators and possible additional mechanisms contributing to their therapeutic effects. We argue that further understanding of the molecular, cellular, network and psychiatric effects of neurosteroids offers the hope of further advances in the treatment of mood and anxiety disorders. Keywords: Allopregnanolone, Brexanolone, SGE-217, Steroid enantiomers, Tonic inhibition |
| Databáze: | OpenAIRE |
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