Possible diagnostic role of antibodies to Crohn’s disease peptide (ACP): results of a multicenter study in a Japanese cohort
| Autor: | Hiroshi Fujita, Fumihito Hirai, Hiroo Abe, Michio Sata, Hiroshi Yoshida, Fukunori Kinjo, Kazuo Ohba, Hiroshi Yamasaki, Kotaro Kuwaki, Kazuya Makiyama, Hirohito Tsubouchi, Mikio Niwa, Keiichi Mitsuyama, Kazuto Kishimoto, Hidetoshi Takedatsu, Ryuichiro Maekawa, Toshiyuki Matsui, Junya Masuda, Teppei Kobayashi |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Colon Enzyme-Linked Immunosorbent Assay Saccharomyces cerevisiae Disease Severity of Illness Index Inflammatory bowel disease Serology Diagnosis Differential Young Adult Asian People Crohn Disease Japan Ileum Internal medicine medicine Humans Prospective cohort study Crohn's disease business.industry Gastroenterology Middle Aged Hepatology medicine.disease Antibodies Bacterial Ulcerative colitis humanities ROC Curve Area Under Curve Immunoglobulin G Immunology Biomarker (medicine) Colitis Ulcerative Female Peptides business |
| Zdroj: | Journal of Gastroenterology. 49:683-691 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s00535-013-0916-9 |
| Popis: | Various noninvasive tests have been studied to screen for patients with Crohn’s disease (CD), and were found to have limited accuracy and sensitivity, particularly in Asian populations. The aim of our study was to explore the possible diagnostic utility of antibodies to the CD peptide (ACP) in patients with CD. In a multicenter study using enzyme-linked immunosorbent assay, serum ACP levels were determined in 196 patients with CD, 210 with ulcerative colitis, 98 with other intestinal diseases, 132 with other inflammatory diseases, and 183 healthy controls. and then examined for correlation to clinical variables. The diagnostic utility of ACP was evaluated by receiver operating characteristics analysis and compared with anti-Saccharomyces cerevisiae antibodies (ASCA). ACP levels were significantly elevated in the CD patients, but not in the other groups that included UC, other intestinal diseases, other inflammatory diseases and the healthy controls. Among these other groups, ACP levels were not significantly different. In the CD patients, ACP had a higher sensitivity and specificity (63.3 and 91.0 %, respectively) than ASCA (47.4 and 90.4 %). ACP levels were negatively associated with disease duration, but not with CDAI, disease location, or medical treatment. ACP, a newly proposed serologic marker, was significantly associated with CD and was highly diagnostic. Further investigation is needed across multiple populations of patients and ethnic groups, and more importantly, in prospective studies. |
| Databáze: | OpenAIRE |
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