Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemia
| Autor: | Walter Fierz, Rudolf P. Wüthrich, Wolfgang Korte, Peter Ammann, Hans Rickli, Daniela Garzoni, Thomas Fehr |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Anemia Renal function Context (language use) Coronary Angiography Gastroenterology Hemoglobins chemistry.chemical_compound chronic renal failure hemic and lymphatic diseases Internal medicine creatinine clearance Prevalence medicine Humans Prospective Studies Registries Aged Creatinine business.industry Middle Aged hemoglobin medicine.disease anemia Endocrinology chemistry Erythropoietin Kidney Failure Chronic Female erythropoietin Hemoglobin business Kidney disease medicine.drug |
| Zdroj: | Kidney International. 66:1206-1211 |
| ISSN: | 0085-2538 |
| Popis: | Interpretation of erythropoietin levels in patients with various degrees of renal insufficiency and anemiaBackgroundChronic renal failure leads to hyporegenerative anemia due to erythropoietin deficiency. The creatinine clearance and hemoglobin levels, at which anemia treatment with recombinant erythropoietin should be started, are unclear. Interpretation of serum erythropoietin levels in the context of renal insufficiency remains controversial and was addressed in this study.MethodsThree hundred and ninety-five patients were randomly chosen out of over 5000 consecutive patients investigated by coronary angiography at a single center between 1997 and 2001. Laboratory values and clinical information were prospectively collected in a central registry. Serum samples were frozen before angiography and now used to measure serum erythropoietin levels and evaluate the relationship between erythropoietin and hemoglobin levels in the context of various degrees of renal insufficiency.ResultsThe patients with the lowest renal function (creatinine clearance |
| Databáze: | OpenAIRE |
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