Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses
| Autor: | Jingbei Liu, Jan Schroers, Udo D. Schwarz, B. Ellen Scanley, Yanhui Liu, Zheng Chen, Christine Broadbridge, Donna Wesolowski, Themis R. Kyriakides, Mariyah Pressley, Sidney Altman, Bettina Cheung, Jagannath Padmanabhan |
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| Rok vydání: | 2016 |
| Předmět: |
Silver
Materials science Alloy Nanotechnology 02 engineering and technology engineering.material Microscopy Atomic Force 010402 general chemistry 01 natural sciences Article Structure-Activity Relationship Phase (matter) Alloys Escherichia coli Combinatorial Chemistry Techniques Thin film Multidisciplinary Amorphous metal Composition dependence 021001 nanoscience & nanotechnology Anti-Bacterial Agents 0104 chemical sciences engineering Development (differential geometry) Glass Zirconium 0210 nano-technology Antibacterial activity Copper Aluminum |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep26950 |
| Popis: | Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategies to optimize compositions out of a vast phase space, making alloy development time consuming and labor intensive. Here, we challenge the conventional paradigm by proposing a combinatorial strategy that enables parallel screening of a multitude of alloys. Utilizing a typical metallic glass forming alloy system Zr-Cu-Al-Ag as an example, we demonstrate how glass formation and antibacterial activity, two unrelated properties, can be simultaneously characterized and the optimal composition can be efficiently identified. We found that in the Zr-Cu-Al-Ag alloy system fully glassy phase can be obtained in a wide compositional range by co-sputtering and antibacterial activity is strongly dependent on alloy compositions. Our results indicate that antibacterial activity is sensitive to Cu and Ag while essentially remains unchanged within a wide range of Zr and Al. The proposed strategy not only facilitates development of high-performing alloys, but also provides a tool to unveil the composition dependence of properties in a highly parallel fashion, which helps the development of new materials by design. |
| Databáze: | OpenAIRE |
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